A postdoctoral position is available in the Traffic, Signaling, and Delivery Group in the Cell Biology Department of the Curie Institute in Paris.
Our work is focused on the study of two trafficking pathways: clathrin-independent endocytosis and retrograde transport between endosomes and the secretory pathway. Both are used by cellular and pathogenic factors that receive increasing attention by the cell biology community. The candidate would join a team of people who dissect the mechanisms by which tubular endocytic plasma membrane invaginations are induced by exogenous and endogenous cargo proteins and are processed by cytosolic machinery. We are using tools and concepts at the intersection of cell biology and membrane biophysics.
The candidate should have strong interest in questions related to membrane transport.
Financing is available. A motivation letter, CV and two contact addresses for references should be sent
to ludger.johannes@curie.fr.
http://www.curie.fr/recherche/themes/detail_equipe.cfm/lang/_fr/id_equipe/101.htm
Recent publications by the group:
Johannes, L., and S. Mayor. 2010. Induced domain formation in endocytic invagination, lipid sorting, and
scission. Cell. 142:507-510.
Römer, W., L.L. Pontani, B. Sorre, C. Rentero, L. Berland, V. Chambon, C. Lamaze, P. Bassereau, C. Sykes, K. Gaus, and L. Johannes. 2010. Actin dynamics drive membrane reorganization and scission in clathrin-independent endocytosis. Cell. 140:540-553.
Ewers, H., W. Römer, A.E. Smith, K. Bacia, S. Dmitrieff, W. Chai, R. Mancini, J. Kartenbeck, V. Chambon, L.
Berland, A. Oppenheim, G. Schwarzmann, T. Feizi, P. Schwille, P. Sens, A. Helenius, and L. Johannes. 2010. SV40 binding to its receptor, GM1, induces membrane invagination, tubulation, and infection. Nat. Cell Biol. 12:11-18.
Johannes, L., and W. Römer. 2010. Shiga toxins - from cell biology to biomedical applications. Nat. Rev. Microbiol. 8:105-116.
Stechmann, B., S.K. Bai, E. Gobbo, R. Lopez, G. Merer, S. Pinchard, L. Panigai, D. Tenza, G. Raposo, B. Beaumelle, D. Sauvaire, D. Gillet, L. Johannes, and J. Barbier. 2010. Inhibition of retrograde transport protects mice from lethal ricin challenges. Cell. 141:231-242.
Römer, W., L. Berland, V. Chambon, K. Gaus, B. Windschiegl, D. Tenza, M.R. Aly, V. Fraisier, J.-C. Florent, D. Perrais, C. Lamaze, G. Raposo, C. Steinem, P. Sens, P. Bassereau, and L. Johannes. 2007. Shiga toxin induces tubular membrane invaginations for its uptake into cells. Nature. 450:670-675.